MATK (CTK), Active(M49-10G)

MATK (CTK), Active(M49-10G)

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Description :Full-length recombinant human MATK (CTK) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_139355

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~83 kDa

Gene Aliases :CHK; CTK; HHYLTK; HYL; HYLTK; LSK

Scientific Background :MATK belongs to tyrosine protein kinase family, CSK subfamily. It inactivates Src family kinase activity by specifically phosphorylating their C-terminal regulatory tyrosine residue and may plays a significant role in the signal transduction of hematopoietic cells (1). MATK binds to the phosphorylated Tyr568/570 sites on c-KIT to which FYN binds and leads to the down-regulation of FYN (2). MATK has been shown to be involved in signaling in some cases of breast cancer.

References :
1. Hirao A. et.al: Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. EMBO J. 16:2342-2351(1997).

2. Price D.J. et.al: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. J. Biol. Chem. 272:5915-5920(1997).

Product Sheets (By Lot #) :

A1363-3.pdf

M2769-4P2.pdf

Research Areas :Cancer, Cytoplasmic Tyrosine Kinases, Cancer, Cytoplasmic Tyrosine Kinases