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Description :Full-length recombinant human MASTL was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_001172303
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~150 kDa
Gene Aliases :GREATWALL; GW; GWL; hGWL; RP11-85G18.2; THC2
Scientific Background :Microtubule associated serine/threonine kinase-like (MASTL) belongs to the MAST family, AGC Ser/Thr protein kinase group. MASTL promotes mitotic progression and cell cycle reentry after DNA damage. Loss of MASTL leads to defects in chromosome condensation, separation, and other aspects of mitotic progression, which is primarily mediated by inhibiting PP2A/B55δ. Overexpression of MASTL is correlated with cancer progression, poor patient survival, and tumor recurrence in various cancers.
1. Wang L, et al. Mastl kinase, a promising therapeutic target, promotes cancer recurrence. Oncotarget. 5:11479-89, 2014.
2. Zhao Y, et al. Roles of Greatwall kinase in the regulation of cdc25 phosphatase. Mol Biol Cell. 19:1317-27, 2008.
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Research Areas :Cancer, Ser/Thr Kinases, Cell Cycle