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MAST2 Protein(M69-31G)

MAST2 Protein(M69-31G)

  • $215.00


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Description :Recombinant human MAST2 protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-792

Genbank Number :BC015816

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~140 kDa

Gene Aliases :MAST205, MTSSK, KIAA0807

Scientific Background :Microtubule associated serine/threonine kinase 2 (MAST2) belongs to the AGC Ser/Thr protein kinase family. MAST2 translocations was identified in invasive breast carcinoma, which occurs during the transition to ductal carcinoma in situ (DCIS) and/or invasive carcinoma. By interacting with Phosphatase and tensin homologue (PTEN) mediated by its PDZ domain, MAST2 plays a key negative role in regulating survival pathways in neuronal cells. The two proteins interact via the PDZ domain of MAST2.

References :
1. Clay MR, et al. MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions. Hum Pathol. 44:2837-44, 2013

2. Delhommel F, et al. Deciphering the unconventional peptide binding to the PDZ domain of MAST2. Biochem J. 469:159-68, 2015

Product Sheets (By Lot #) :

P1699-2.pdf

Research Areas :WNT Signaling, Ser/Thr Kinases, Cancer