MANF(M805-40N)

MANF(M805-40N)

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Description :Recombinant Human MANF was expressed in E. coli cells.

Species :Human

Expression System:E.coli

Genbank Number :P55160

Storage, Stability and Shipping :The lyophilized protein is stable for at least one year from date of receipt at -70oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :<1.0 EU/μg of recombinant protein as determined by the LAL method

Molecular Weight :18.4 kDa

Gene Aliases :Arginine-rich protein, Protein ARMET, ARP, Recombinant Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)

Reconstitution Protocol :Reconstitute at 200 μg/mL in PBS

Scientific Background :MANF is a neurotrophic factor found mainly in central nervous tissues where it may remain localized to the endoplasmic reticulum/Golgi apparatus, or secreted. It has been shown that MANF plays an important role in protecting cells against tunicamycin and thapsigargin -induced cell death. Without MANF, cells become increasingly vulnerable to the aforementioned drugs. Also, MANF is structurally homologous to CDNF.

Sample Cell Assay Data :

Purity :Recombinant Human MANF resolved on a 15% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250

Product Sheets (By Lot #) :

G3211-88.pdf

Research Areas :Cancer