MAK, Active(M01-10G)

MAK, Active(M01-10G)

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Description :Recombinant full-length human MAK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :BC039825

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~78 kDa

Gene Aliases :dJ417M14.2, ALPK3

Scientific Background :MAK or male germ cell-associated kinase is a serine/threonine protein kinase related to kinases involved in cell cycle regulation which is expressed almost exclusively in the testis, primarily in germ cells. MAK plays an important role in spermatogenesis (1). MAK is also required for retinal photoreceptor survival (2). MAK is a regulator of ciliary length, as a cause of retinitis pigmentosa.

References :
1. Matsushime, H. et.al: A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Molec. Cell. Biol. 10: 2261-2268, 1990.

2. Omori, Y. et.al: Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc. Nat. Acad. Sci. 107: 22671-22676, 2010.

Product Sheets (By Lot #) :

Z1359-3.pdf

G1153-9.pdf

Research Areas :Cell Cycle, Neurobiology, Ser/Thr Kinases, Neurobiology, Cell Cycle, Ser/Thr Kinases