MUSK, Active(M60-11G)
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Description :Recombinant human MUSK (519-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :519-end
Genbank Number :NM_005592
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~63 kDa
Gene Aliases :MGC126323, MGC126324
Scientific Background :MUSK is a receptor tyrosine kinase necessary for neuromuscular junction formation (1). MUSK gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MUSK members play a key role in growth and differentiation of those cell types. Agrin signals through MUSK to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. DOK7, a MUSK-interacting cytoplasmic protein, is essential for MUSK activation in cultured myotubes. MUSK also plays a critical role in the development of normal blood vessels (2).
References :
1. Okada, K. et al: The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science,. 2006; 312(5781):1802-5
2. Kim, C.H. et al: Regulation of MuSK expression by a novel signaling pathway.J Biol Chem. 2003;278(40):38522-7.
Product Sheets (By Lot #) :
Research Areas :Neurobiology, Receptor Tyrosine Kinases, Neurobiology, Receptor Tyrosine Kinases