MOS Protein(M57-34G)
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Description :Recombinant full-length human MOS was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_005372
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~66 kDa
Gene Aliases :MGC119962; MGC119963; MSV
Scientific Background :MOS or v-mos Moloney murine sarcoma viral oncogene homolog is a serine/threonine kinase that activate the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (1). The early site-specific phosphorylation of CPEB , which was catalyzed by Eg2 is essential for the polyadenylation of c-mos mRNA, subsequent translation of c-mos, and oocyte maturation (2). The interaction with and phosphorylation of MYOD by MOS enhances muscle differentiation. MOS is an essential component of the cytostatic factor that acts almost exclusively in the second meiotic metaphase arrest.
References :
1. Prasad, C. K. et.al: Mos 3-prime UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. Molec. Reprod. Dev. 75: 1258-1268, 2008.
2. Mendez, R. et.al: Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature 404: 302-307, 2000.
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Research Areas :Cell Cycle, Ser/Thr Kinases, Cell Cycle, Ser/Thr Kinases