c-MER, Active(M51-172G)
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Description :Recombinant mouse c-MER (528-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Mouse
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :528-end
Genbank Number :NM_008587
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~83 kDa
Gene Aliases :MERTK, Eyk; Mer; nmf12; Nyk
Scientific Background :c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family (1). The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product (2).
References :
1. Graham, D. K. et al: Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 5: 647-657, 1994.
2. Gal, A. et al: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nature Genet. 26: 270-271, 2000.
Product Sheets (By Lot #) :
Research Areas :Cardiovascular Disease, Inflammation, Receptor Tyrosine Kinases