METTL16, Active (M336-380G)

METTL16, Active (M336-380G)

  • $259.00


Description :Recombinant full-length human METTL16 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_024086

Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight :~98 kDa

Gene Aliases :METT10D; MGC3329

Scientific Background :METTL16 (Methyltransferase-like protein 16) is an RNA N6-methyltransferase that methylates adenosine residues at the N6 position of a subset of RNAs. METTL16 methylates the 3’ UTR of the SAM synthetase (MAT2A) mRNA and U6 snRNA (1,2), thereby regulating S-adenosylmethionine homeostasis as well as pre-mRNA splicing. These modifications on viral RNAs are believed to influence the expression of viral genes, the replication of virus and the generation of progeny virions (3).

References :
1. Shima, H. et al: S-Adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1. Cell Rep. 2017,21:3354–3363.

2. Warda, AS. et al: Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 2017,18:2004–2014.

3. Dang, W. et al: N6-methyladenosine and viral infection. Front. Microbiol. 2019,10:417.

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Research Areas :Cancer, Neurobiology