ERK3 (MAPK6), Active(M31-10G)
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Description :Recombinant full-length human ERK3 (MAPK6) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_002748
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~135 kDa
Gene Aliases :ERK3; MAPK6; HsT17250; p97MAPK; PRKM6
Scientific Background :ERK3 (MAPK6) or mitogen-activated protein kinase 6 is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases) which also known as extracellular signal-regulated kinases (ERKs) that are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals and tyrosine phosphorylated in response to insulin and NGF (1). ERK3 is highly expressed in various human tissues, most abundantly in skeletal muscle (2).
References :
1. Boulton, T. G.et.al: ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65: 663-675, 1991.
2. Meloche, S. et.al: Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. Oncogene 13: 1575-1579, 1996.
Product Sheets (By Lot #) :
Research Areas :Ser/Thr Kinases, Neurobiology, Invasion/Metastasis, Cardiovascular Disease, Cancer, Apoptosis/Autophagy, ERK/MAPK Pathway, Angiogenesis