MEK6, Active(M07-10G)
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Description :Recombinant full-length human MEK6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :BC012009
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~64 kDa
Gene Aliases :MAP2K6, MAPKK6, MKK6, PRKMK6, SAPKK3, SKK3, SEK3
Scientific Background :MEK6 or MAP2K6(mitogen-activated protein kinase kinase 6) is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase that also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MEK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress (1). As an essential component of p38 MAP kinase mediated signal transduction pathway, MEK6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis (2).
References :
1. Han, J..et.al: Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem. 271: 2886-2891, 1996.
2. Mao, Z.et.al: Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science 286: 785-790, 1999.
Product Sheets (By Lot #) :
Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases, Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases