MKK4, Active (M05-10H)
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Description :Recombinant human full-length MKK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_003010
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~46 kDa
Gene Aliases :MAP2K4, JNKK, MEK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4
Scientific Background :MKK4 is a member of the mitogen-activated protein kinase family and is involved in the stress-activated protein kinase pathway where it phosphorylates c-Jun NH2-terminal kinase (1). MKK4 is part of a signaling system that is stimulated in the presence of stress to the cell (including chemotherapy), and it controls differentiation and programmed cell death (apoptosis). MKK4 is central component of signal transduction pathways induced by mitogens and stresses. MKK4 genetic inactivation has been observed in a subset of pancreatic carcinomas, implicating deregulation of the stress-activated protein kinase pathway in pancreatic carcinogenesis (2).
References :
1. Karl Deacon, K. et al: Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3. J. Biol. Chem.1997; 272 ( 22): 14489-14496.
2. 2. Wei, X. et al: MAP2K4/MKK4 Expression in Pancreatic Cancer. Clinical Cancer Res. 2004; 10, 8516-8520.
Product Sheets (By Lot #) :
Research Areas :Cancer, Ser/Thr Kinases