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LYS6K2(R15-900)

LYS6K2(R15-900)

  • $105.00


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Description :S6K inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :NF

Molecular Formula :C21H19F4N7

Appearance :Yellow solid

Melting Point :276-280oC

Molecular Weight :445.4

Purity :>97% (HPLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (1 mg/ml); DMF (3 mg/ml, warm)

Aliases :4-(4-(4-(4-fluoro-3-(trifluoromethyl) phenyl)-1-methyl-1H-imidazol-2-yl) piperidin-1-yl)-1H-pyrazolo [3,4-d] pyrimidine

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20oC for up to 3 months.

Scientific Background :A selective inhibitor of the p70 ribosomal S6 kinase (S6K) (1). Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 uM with no activity at GSK3beta and Erk1/2 at 10 uM (2). Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K (2). Cell permeable.

References :
1. TR Fenton et al. Int. J. Biochem. Cell Biol. 2011 43:47

2. S Li et al. Proc. Natl. Acad. Sci. USA 2010 107:3441

Molecular Structure :

Product Sheets (By Lot #) :

T2257-82.pdf

Research Areas :Cancer, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, Apoptosis/Autophagy, Angiogenesis