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LYN B, Active(L13-10G)

LYN B, Active(L13-10G)

  • $226.00


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Description :Recombinant full-length human LYN B was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :BC059394

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~85 kDa

Gene Aliases :JTK8; FLJ26625; p65

Scientific Background :LYN is a 56 kd tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck, v-yes, v-fgr and v-src and is expressed in a variety of tissues (1). LYN is expressed preferentially in B cells and can be coimmunoprecipitated with IgM suggesting that LYN is physically associated with membrane-bound IgM, and participates in antigen-mediated signal transduction (2). Crosslinking of membrane-bound IgM with antibody induces rapid increase in activities of LYN and LYN-associated phosphatidylinositol 3-kinase.

References :
1. Yamanashi, Y. et al: The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol. 1987 Jan;7(1):237-43.

2. Yamanashi, Y. et al: Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science. 1991 Jan 11;251(4990):192-4.

Product Sheets (By Lot #) :

B212-1.pdf

Research Areas :Cancer, Inflammation, Cardiovascular Disease, AKT/PKB Pathway, Cellular Stress, Cytoplasmic Tyrosine Kinases, Cancer, Inflammation, Cardiovascular Disease, AKT/PKB Pathway, Cellular Stress, Cytoplasmic Tyrosine Kinases