LY-364947(T07-901)

LY-364947(T07-901)

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Description :ALK5 Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :396129-53-6

Molecular Formula :C17H12N4

Appearance :Brown Powder

Molecular Weight :272.31

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/ml)

Aliases :4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone; HTS-466284

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 year. Store solutions at -20oC for up to 3 months.

Scientific Background :Selective ALK5 inhibitor, IC50=59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively1. Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin expression and MDA-MB-231 cell invasion2.

References :
1. JS Sawyer et al. J. Med. Chem. 2003 46:3953

2. SR Shiou et al. J. Biol. Chem. 2006 281:33971

3. ME Hardee et al. Cancer Res. 2012 72:4119

Molecular Structure :

Product Sheets (By Lot #) :

D3370-8.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, Ser/Thr Kinases, WNT Signaling