LY-294002(P27-900C)

LY-294002(P27-900C)

  • $105.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :PI3K inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :154447-36-6

Molecular Formula :C19H17NO3

Appearance :White to pale-yellow powder

Melting Point :182-183oC

Molecular Weight :307.2

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (100 mg/ml)

Aliases :2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Highly selective inhibitor of phosphatidylinositol 3-kinase (IC50 = 0.31, 0.73, 1.06 and 6.60 uM for PI 3-Kbeta, PI 3-Kalpha, PI 3-Kdelta and PI 3-Kgamma respectively) (1). Inhibits autophagy in rat hepatocytes (IC50 = 10 uM) (2). An extremely useful tool for determining the role of PI 3-K in cellular signaling (3).

References :
1. CJ Vlahos et al. J. Biol. Chem. 1994 269:5241

2. EF Blomaart et al. Eur. J. Biochem. 1997 243:240

3. S Chasserot-Golaz et al. J. Neurochem. 1998 70:2347

Molecular Structure :

Product Sheets (By Lot #) :

T2257-60.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Lipid Kinases