LTK, Active(L11-11G)

LTK, Active(L11-11G)

  • $226.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :Recombinant human LTK (498-796) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :498-796

Genbank Number :NM_002344

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~70 kDa

Gene Aliases :TYK1

Scientific Background :LTK is a member of the ros/insulin receptor family of tyrosine kinases. LTK express a gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain and it may encode a signal transduction subunit for one or more of the hematopoietic receptors (1). LTK gene produces not only the putative receptor tyrosine kinase for an unknown ligand but also multiple protein products that may have different functions (2). LTK causes upregulation of the PI3K pathway and possibly form a genetic component of susceptibility to abnormal proliferation of self-reactive B cells in SLE (3).

References :
1. Ben-Neriah, Y. et.al: Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.(Letter) Nature 333: 672-676, 1988.

2. Toyoshima, H. et.al: Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. Proc. Nat. Acad. Sci. 90: 5404-5408, 1993.

3. Li, N. et.al: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum. Molec. Genet. 13: 171-179, 2004.

Product Sheets (By Lot #) :

T1003-1.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases