LOXL2 Protein (L262-31G)
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Description : Recombinant human LOXL2 (519-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : 519-end
Genbank Number : BC000594
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~65 kDa
Gene Aliases : LOR2, WS9-14
Scientific Background : LOXL2 is a member of the lysyl oxidase gene family which is essential for the biogenesis of connective tissue. LOXL2 encodes an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. LOXL2 may play an important role in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family (1). LOXL2 may mediate fibroblast activation through enzymatic crosslinking of fibrillar collagen and local matrix tention, resulting in activation of TGFβ1 signaling (2).
1. HJourdan-Le Saux, C.et.al: The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. J. Biol. Chem. 274: 12939-12944, 1999.
2. Barry-Hamilton, V. et.al: Allosteric inhibition of lysyl oxidase-like-2 impedes the development of pathologic microenvironment. Nature Med. 16: 1009-1017, 2010.
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Research Areas : Cancer, Metabolic Disorder