LOX Protein (L260-31G)
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Description : Recombinant human LOX (169-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : 169-end
Genbank Number : BC074872
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : 57 kDa
Gene Aliases : Lysyl oxidase
Scientific Background : LOX or lysyl oxidase is an extracellular copper enzyme that initiates the cross-linking of collagens and elastin. LOX catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin (1). LOX plays an important role in tumor suppression (2). LOX may be required to create a niche permissive for metastatic growth and it is essential for hypoxia-induced metastasis.
1. Hamalainen, E.-R. et.al: Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. Genomics 11: 508-516, 1991.
2. Kaneda, A. et.al: Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res. 64: 6410-6415, 2004
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Research Areas : Cancer, Cardiovascular Disease, Metabolic Disorder,