LFM-A13(B10-901)

LFM-A13(B10-901)

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Description :BTK inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :62004-35-7

Molecular Formula :C11H8Br2N2O2

Appearance :Yellow powder

Melting Point :145-146oC

Molecular Weight :360.0

Purity :98% (TLC: 2:8 CH3OH:CH2Cl2; Rf=0.53); NMR (Conforms)

Solubilization :DMSO (10 mg/ml) and ethanol (15 mg/ml)

Aliases :2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM (1) and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM (2).

References :
1. S Mahajan et al. J. Biol. Chem. 1999 274:9587

2. A Vassilev et al. J. Biol. Chem. 1999 274:1646

Molecular Structure :

Product Sheets (By Lot #) :

T2257-12.pdf

Research Areas :Cancer, Inflammation, NfkB Pathway, Cytoplasmic Tyrosine Kinases