Lestaurtinib(F12-901)

Lestaurtinib(F12-901)

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Description :FLT3/TRKA inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :111358-88-4

Molecular Formula :C26H21N3O4

Appearance :White to off-white solid

Melting Point :N/A

Molecular Weight :439.5

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (100 mg/ml); or ethanol (20 mg/ml)

Aliases :
1. CEP-701

2. KT-5555

Storage and Stability :Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 2 months.

Scientific Background :Potent and selective FLT3 inhibitor (IC50= 2.0 nM) (1,2). Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders (3).

References :
1. M Lewis et al. Expert Opin. Investig. Drugs 2003 12:1951

2. P Chen et al. J. Biol. Chem. 2005 280:5361

3. EO Hexner et al. Blood 2008 111:5663

Molecular Structure :

Product Sheets (By Lot #) :

T2257-59.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases, Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Angiogenesis, Receptor Tyrosine Kinases