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Description :Human active form Leptin (22-167) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Species :Human

Tag :

Expression System:E.coli

Sequence :22-167

Genbank Number :NP_000221

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :Less than 0.1 ng/ug (IEU/ug) of Leptin.

Molecular Weight :~14.5 kDa

Gene Aliases :OB; OBS; FLJ94114; LEP

Scientific Background :Leptin is a serum protein produced by adipocytes that play a main role in the regulation of body fat. Leptin is a growth factor in colonic epithelial cells and one that may provide a biological explanation for the observed associations between obesity, physical activity, and colon cancer (1). Leptin appears to be able to control the proliferation of both normal and malignant breast epithelial cells and used for normal mammary gland development (2).

References :
1. Hardwick JC. et.al : Leptin is a growth factor for colonic epithelial cells. Gastroenterology. 2001 Jul;121(1):79-90.

2. X Hu. et.al: Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst. 2002 Nov 20;94(22):1704-11.

Product Sheets (By Lot #) :


Research Areas :AKT/PKB Pathway, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, p38 Pathway, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, JAK/STAT Pathway