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Lenvatinib(K01-901)

Lenvatinib(K01-901)

  • $83.00


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Description :Inhibitor of KDR (VEGFR2)

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :417716-92-8

Molecular Formula :C21H19ClN4O4

Appearance :white powder

Molecular Weight :426.90

Purity :>98% (TLC); NMR (conforms)

Solubilization :May be dissolved in DMSO (20 mg/ml)

Aliases :4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide; E7080

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :A potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively1. Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively1.

References :
1. J Matsui et al. Int. J. Cancer. 2008 122:664

Molecular Structure :

Product Sheets (By Lot #) :

D3095-1.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, p38 Pathway, Receptor Tyrosine Kinases