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LCK, Active(L03-10G)

LCK, Active(L03-10G)

  • $226.00


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Description :Recombinant full-length human LCK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_005356

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~84 kDa

Gene Aliases :YT16, p56lck, pp58lck

Scientific Background :LCK (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene (1). Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers (2).

References :
1. Fischer, S. et al: The amino terminal region of the p56 lck from LSTRA exerts negative modulation on the tyrosine kinase activity. Biochem Biophys Res Commun. 1987 Mar 30;143(3):819-26.

2. Veillette, A. et al: Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res. 1987 Sep-Oct;1(4):357-74.

Product Sheets (By Lot #) :

H258-1.pdf

C1959-3.pdf

C2007-6.pdf

Research Areas :Cancer, Inflammation, NfkB Pathway, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases, Cancer, Inflammation, NfkB Pathway, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases