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LATS2, Active(L02-11G)

LATS2, Active(L02-11G)

  • $226.00


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Description :Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :480-1088

Genbank Number :NM_014572

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~110 kDa

Gene Aliases :none

Scientific Background :LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction (1). LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity (2).

References :
1. Aylon, Y. et.al: A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20: 2687-2700, 2006.

2. McPherson, J. P. et.al: Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 23: 3677-3688, 2004.

Product Sheets (By Lot #) :

I206-1.pdf

H2822-8.pdf

W3029-12.pdf

Research Areas :Cell Cycle, Cardiovascular Disease, Cancer, Apoptosis/Autophagy, Ser/Thr Kinases, Cancer, Cardiovascular Disease, Apoptosis/Autophagy, Cell Cycle