LRRK1, Active (L09-11G)
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Description :Recombinant human LRRK1 (622-1610) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :622-1610
Genbank Number :NM_024652
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~210 kDa
Gene Aliases :RIPK6; Roco1; FLJ23119; KIAA1790
Scientific Background :LRRK1, also called leucine-rich repeat kinase 1, is highly expressed in testis, placenta, prostate, and muscle, with moderate expression in brain, pancreas, small intestine, stomach, and spleen. Mutations in LRRK1 corresponding to Parkinson disease-8 -associated mutations found in LRRK2, significantly reduced LRRK1 kinase activity (1). LRRK1 expression in all mouse brain regions examined, with highest expression in olfactory bulb (2). LRRK1 functions as a GDP/GTP-binding protein and its kinase activity is stimulated upon binding of GTP to the ROC domain.
References :
1. Korr, D.et.al: LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. Cell. Signal. 18: 910-920, 2006.
2. Taylor, J. P.et.al: Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease. Neurogenetics 8: 95-102, 2007
Product Sheets (By Lot #) :
Research Areas :Neurobiology