LMTK3 Protein(L08-35G)

LMTK3 Protein(L08-35G)

  • $215.00


Description :Recombinant mouse LMTK3 (63-484) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Mouse

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :63-484

Genbank Number :NM_001005511

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~75 kDa

Gene Aliases :AATYK3; MGC90743

Scientific Background :LMTK3, or Lemur tyrosine kinase 3, belongs to the LMR subfamily of tyr protein kinases. LMTK3 decreases the activity of protein kinase C (PKC) and also leads to phosphorylation of AKT (Ser473), thereby increasing binding of forkhead box O3 (FOXO3) to the ESR1 promoter. LMTK3 phosphorylates ERα, protecting it from proteasomal degradation in vitro. Knockdown of LMTK3 leads to a reduction of tumor volume in an orthotopic mouse model and abrogates proliferation of ERα+ but not ERα- cells, indicative of its role in ERα activity. These findings reveal LMTK3 as a new therapeutic target for breast cancer (1).

References :
1. Giamas G et al: Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nat Med. 2011 Jun;17(6):715-9.

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Research Areas :Cancer, Ser/Thr Kinases, Cancer, Ser/Thr Kinases