KU-55933(A26-901)

KU-55933(A26-901)

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Description :ATM kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :587871-26-9

Molecular Formula :C21H17NO3S2

Appearance :Tan powder

Molecular Weight :395.50

Purity :>98% (TLC); NMR (conforms)

Solubilization :May be dissolved in DMSO (40 mg/ml); or ethanol (20 mg/ml)

Aliases :2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 months.

Scientific Background :Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively1. Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro2.

References :
1. I Hickson et al. Cancer Res. 2004 64:9152

2. E Crescenzi et al. Clin. Cancer Res. 2008 14:1877

Molecular Structure :

Product Sheets (By Lot #) :

D3370-12.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, Lipid Kinases, Metabolic Disorder, Ser/Thr Kinases