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KT-5823(P78-900)

KT-5823(P78-900)

  • $138.00


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Description :PKG inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :126643-37-6

Molecular Formula :C29H25N3O5

Appearance :White to off-white powder

Melting Point :N/A

Molecular Weight :495.5

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/ml); or DMF (20 mg/ml)

Aliases :None

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Selective protein kinase G inhibitor (Ki = 0.23, 4 and > 10 uM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity (IC50 of 60 nM) in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 uM. Cell permeable.

References :
1. H Kase et al. Biochem. Biophys. Res. Commun. 1987 142:436

2. Gadbois et al . Proc.Natl.Acad.Sci.1996 89:8626.

3. Murthy and Makhlouf. Am.J.Physiol. 1995 268:C171.

4. Smolenski et al. Naunyn Schmiedebergs Arch.Pharmacol. 1998 358:134

Molecular Structure :

Product Sheets (By Lot #) :

T2257-47.pdf

Research Areas :Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Ser/Thr Kinases