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KDM5B Protein(K425-31BG)

KDM5B Protein(K425-31BG)

  • $215.00


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Description :Recombinant mouse KDM5B (1-753) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Mouse

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-753

Genbank Number :BC057318

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~112 kDa

Gene Aliases :Jarid1b;PUT1;Plu1;PLU-1;Rb-Bp2; AW556288; RBBP2H1A; mKIAA4034

Scientific Background :KDM5B is a lysine (K)-specific demethylase 5B which is highly expressed in testis and shows the lowest expression in skeletal muscle (1). KDM5B is a histone H3 lysine 4 (H3K4) demethylase up-regulated in prostate cancer and associated with androgen receptor where it regulated its transcriptional activity in reporter gene assays (2). Overexpression of KDM5B in HeLa cells results in loss of tri-, di-, and monomethyl H3K4, but does not alter the methylation status of H3K9 or H3K36. A KDM5B containing highly conserved putative DNA/chromatin binding motif is specifically up-regulated in breast cancer.

References :
1. Kashuba, V. et.al: Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). Europ. J. Hum. Genet. 8: 407-413, 2000.

2. Xiang, Y. et.al: JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc. Nat. Acad. Sci. 104: 19226-19231, 2007.

Product Sheets (By Lot #) :

F600-3.pdf

Research Areas :Cancer, Cell Cycle, Inflammation, Cancer, Inflammation, Cell Cycle