KAT6B (MYST4), Active (K315-381BG)
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Description : Recombinant human KAT6B (MYST4) (431-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : 431-end
Genbank Number : NM_012330
Specific Activity : Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Acetyltransferase Assay
Molecular Weight : ~76 kDa
Gene Aliases : MYST4; DKFZp313G1618; FLJ90335; KIAA0383; MORF; MOZ2; qkf; querkopf
Scientific Background : KAT6B is the catalytic subunit of the histone acetyltransferase (HAT) elongator complex, which is ubiquitously expressed in adult human tissues. KAT6B is a 1,781aa-residue protein that contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at its C terminus (1). These domains of KAT6B may be involved in both positive and negative regulation of transcription and also involved in cerebral cortex development. KAT6B is important for cellular aging, proliferation, positive and negative transcriptional regulation and DNA damage repair (2).
1. Champagne, N. et.al: Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. J. Biol. Chem. 274: 28528-28536, 1999.
2. Pena AN, et.al: The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging. DOI: 10.1196/annals: 299–305, April 2007.
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Research Areas : Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway,