Announcement : SignalChem has changed its corporate name from “SignalChem Pharmaceutical Inc.” to “SignalChem Biotech Inc.” effective March 20th 2019.
KAT5 (TIP60), Active (K314-380G)

KAT5 (TIP60), Active (K314-380G)

  • $259.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description : Full-length recombinant human KAT5 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species : Human

Tag : GST tag

Expression System : Sf9 insect cells using baculovirus

Sequence : Full Length

Genbank Number : NM_006388

Specific Activity : Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Acetyltransferase Assay

Molecular Weight : ~88 kDa 

Gene Aliases : cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60

Scientific Background :  KAT5 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). KAT5 was originally isolated as an HIV-1 TAT-interactive protein that plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins (1). KAT5 protein is a histone acetylase that is involved in DNA repair and apoptosis and plays an important role in signal transduction. KAT5 acts as a cofactor of TAT that is involved in the regulation of HIV gene expression. KAT5 is also a co-regulator of transcription factors that either promote or suppress tumorigenesis (2).

References : 
1. Kamine, J. et.al: Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transcriber. Virology 216: 357-366, 1996.

2. Gorrini, C. et.al: Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature 448: 1063-1067, 2007.

Product Sheets: (by Lot #):

E024-6.pdf

A1425-2.pdf

G1223-3.pdf

K1527-3.pdf

K1539-1.pdf

P1701-9.pdf

Research Areas : Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway,