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KAT3B (EP300) Protein(K312-31BG)

KAT3B (EP300) Protein(K312-31BG)

  • $215.00


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Description :Recombinant human KAT3B (EP300) (532-1153; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :532-1153; contains the catalytic domain

Genbank Number :NM_001429

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~120 kDa

Gene Aliases :KAT3B; EP300; p300

Scientific Background :KAT3B (also known as EP300) encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein that functions as a histone acetyltransferase. KAT3B regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. KAT3B binding is a highly accurate process and can be used for identifying enhancers and their associated activities (1). KAT3B is also useful in the study of the role of tissue-specific enhancers in human biology and diseases on a genome wide scale. Defects in KAT3B gene are a cause of Rubinstein-Taybi syndrome that play a important role in epithelial cancer and act as a classic tumor suppressor gene (2).

References :
1. Visel, A. et.al: ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457: 854-858, 2009.

2. Gayther, S. A. et.al: Mutations truncating the EP300 acetylase in human cancers. Nature Genet. 24: 300-303, 2000.

Product Sheets (By Lot #) :

E012-1.pdf

I279-3.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Cell Cycle, Invasion/Metastasis