KDM2A Protein(K422-31G)

KDM2A Protein(K422-31G)

  • $215.00


Description :Recombinant human KDM2A (1-748) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-748

Genbank Number :NM_012308

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~115 kDa

Gene Aliases :CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA

Scientific Background :KDM2A or lysine (K)-specific demethylase 2A is a member of the F-box protein family that are components of the modular E3 ubiquitin protein ligases called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination (1). KDM2A belongs to the Fbls class and, in addition to the presence of an F-box, contains at least six highly degenerated leucine-rich repeats which play a role in epigenetic silencing. The demethylase activity of the JmjC domain-containing proteins is conserved from yeast to human (2).

References :
1. Cenciarelli, C.et.al: Identification of a family of human F-box proteins. Curr. Biol. 9: 1177-1179, 1999.

2. Tsukada, Y. et.al: Histone demethylation by a family of JmjC domain-containing proteins. Nature 439: 811-816, 2006.

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Research Areas :Cancer, Cell Cycle, Inflammation, Cancer, Inflammation, Cell Cycle