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K252B(K10-900E)

K252B(K10-900E)

  • $127.00


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Description :Kinase inhibitor (pan)

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :99570-78-2

Molecular Formula :C26H19N3O5

Appearance :White to off-white powder

Melting Point :N/A

Molecular Weight :453.5

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (1 mg/ml); or DMF (1 mg/ml)

Aliases :None

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Potent pan-specific protein kinase inhibitor: PKA (Ki = 90 nM), PKC (Ki = 20 nM), PKG (Ki = 100 nM) (1) as well as other kinases. Cell impermeable (2).

References :
1. H Kase et al. Biochem. Biophys. Res. Commun. 1987 142:436

2. K Makino et al. PLoS One 2012 7:e41049

Molecular Structure :

Product Sheets (By Lot #) :

T2257-45.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, PKA/PKC Pathway, WNT Signaling, Apoptosis/Autophagy, Cell Cycle, Cellular Stress, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases, Cytoplasmic Tyrosine Kinases, Receptor Tyrosine Kinases