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K252A(K10-900D)

K252A(K10-900D)

  • $430.00


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Description :Kinase inhibitor (pan)

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :99533-80-9

Molecular Formula :C27H21N3O5

Appearance :White to off-white powder

Melting Point :N/A

Molecular Weight :467.5

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (100 mg/ml)

Aliases :None

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Potent pan-specific protein kinase inhibitor: PKA (Ki = 18 nM), PKC (Ki = 25 nM) PKG (Ki = 20 nM) (1). Inhibits CaMK (Ki = 1.8 nM) (2) and phosphorylase kinase (IC50 = 1.7 nM) (3) as well as other kinases (4). Induces apoptosis (5). Cell permeable.

References :
1. H Kase et al. Biochem. Biophys. Res. Commun. 1987 142:436

2. Y Hashimoto et al. Biochem. Biophys. Res. Commun. 1991 181:423

3. MM Berg et al. J. Biol. Chem. 1992 267:13

4. UT Ruegg et al. Trends Pharmacol. Sci. 1989 10:218

5. T Mohri et al. Cancer Invest. 1999 17:391

Molecular Structure :

Product Sheets (By Lot #) :

T2257-44.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, PKA/PKC Pathway, WNT Signaling, Apoptosis/Autophagy, Cell Cycle, Cellular Stress, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases, Cytoplasmic Tyrosine Kinases, Receptor Tyrosine Kinases