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JAK1 Mutant (E966V) Protein(J01-12CG)

JAK1 Mutant (E966V) Protein(J01-12CG)

  • $226.00


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Description :Recombinant human JAK1 (E966V) (438-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :438-end (E966V)

Genbank Number :NM_002227

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :~105 kDa

Gene Aliases :JAK1A, JAK1B

Scientific Background :JAK1 is a member of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein that is involved in the interferon-alpha/beta and -gamma signal transduction pathways (1). JAK1 plays an essential and nonredundant role in promoting biologic responses induced by a select subset of cytokine receptors, including those in which JAK utilization is thought to be nonspecific(2).

References :
1. Muller, M.et.al: The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366: 129-135, 1993.

2. Rodig, S. J.et.al: Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93: 373-383, 1998.

RESTRICTION: :All orders for customers in the USA must be placed directly through SignalChem (This product cannot be purchased through Distributors in the USA). This product shall not be used to commercially screen drug molecules being developed as JAK1 or JAK2 inhibitors nor for any in vitro diagnostic purposes. Any such activity will be outside the scope of the research use only label license. The product is protected by the following patents: US5,910,426; US5,852,184; US5,821,069; US5,716,818,US5,658,791.

Product Sheets (By Lot #) :

P1746-2.pdf

Research Areas :Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway