Anti-phospho-JAK1 (Tyr1022)(J01-65R)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the JAK1 protein phosphorylated at tyrosine 1022
Cited Applications :IHC
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1022
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-phospho-JAK1 (Tyr1022) antibody.
Scientific Background :JAK1 is a member of the Janus family of tyrosine kinases which are involved in cytokine receptor-mediated intracellular signal transduction (1). Upon stimulation by cytokines, JAK1 undergoes autophosphorylation. In turn, activated JAK1 is responsible for phosphorylating several signaling proteins, including STATs. Phosphorylated STATs dimerize and translocate to the nucleus where they regulate transcription of genes involved in growth, survival and differentiation. Phosphorylation of JAK1 at Tyr1022 and Tyr1023 is associated with cells that are undergoing proliferation (2).
References :
1. Leonard, W J. et al : Jaks and STATs: biological implications. Annu Rev Immunol. 1998;16:293-322.
2. Trenarry, M K. et al : JAK/STAT signaling and human in vitro myogenesis. BMC Physiol. 2011 Mar 9;11:6.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway, Cancer, Inflammation, Cardiovascular Disease, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases