IRAK4 (catalytic domain), Active (I12-11G)

IRAK4 (catalytic domain), Active (I12-11G)

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Description :Recombinant human IRAK4 (104 a.a.-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :104 a.a. end

Genbank Number :BC013316

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :68 kDa

Gene Aliases :IPD1, REN64, NY-REN-64

Scientific Background :Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important mediator in the signal transduction of Toll-like receptor (TLR) and IL1R family members (1). IRAK4 is involved in the Toll-like receptor signaling pathway leading to Apoptosis. IRAK4 has molecular functions like protein binding, ATP binding, kinase activity and magnesium ion binding. Toll/IL-1 receptor family members like IRAK4 are central components of host defense mechanisms in a variety of species (2). One well conserved element in their signal transduction is the Ser/Thr kinase activity which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol.

References :
1. Li, S. et al: IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. USA. 2002; 99:5567-72.

2. Suzuki, N. et al: IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol. 2002; 23:503-6

Product Sheets (By Lot #) :

W3340-1.pdf

Research Areas :Inflammation, p38 Pathway, NfkB Pathway, Ser/Thr Kinases