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IRAK1 (catalytic domain), Active (I09-11G)

IRAK1 (catalytic domain), Active (I09-11G)

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Description :Recombinant human IRAK1 (194-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :194-end

Genbank Number :NM_001569

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :85 - 100 kDa

Gene Aliases :IRAK, Pelle

Scientific Background :IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. The exposure of HeLa cells or human embryonic kidney cells overexpressing IL1R to IL1 caused rapid association of IRAK with the IL1R complex and phosphorylation of IRAK (1). IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus (2).

References :
1. Cao, Z.et.al: IRAK: a kinase associated with the interleukin-1 receptor. Science 271: 1128-1131, 1996.

2. Jacob, C. O. et.al: Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc. Nat. Acad. Sci. 106: 6256-6261, 2009.

Product Sheets (By Lot #) :

W3196-3.pdf

Research Areas :Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases, Inflammation