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Description : Human active form IP-10 (22-98) with N-terminal His-tag was expressed in E. coli cells and purified by proprietary chromatographic techniques.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : tored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Cell Assay
Endotoxin Level : Less than 0.1 ng/ug (IEU/ug) of IP-10.
Molecular Weight : ~13.2 kDa
Gene Aliases : C7; IFI10; INP10; crg-2; mob-1; SCYB10; gIP-10; CXCL10
Scientific Background : IP10 or interferon gamma inducible protein 10 is a member of the CXC chemokine family that plays a role in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. IP10 participate in the regulation of angiogenesis during inflammation and tumorigenesis (1). IP10 plays a role in the generation and delivery of an effector T-cell response (2).
1. Angiolillo, A. L. et.al: Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182: 155-162, 1995.
2. Dufour, J. H. et.al: IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J. Immun. 168: 3195-3204, 2002.
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Research Areas : AKT/PKB Pathway, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway,