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IP-10 (CXCL10)(I838-40BN)

IP-10 (CXCL10)(I838-40BN)

  • $380.00


Description :Recombinant Human IP-10 (CXCL10) was expressed in E. coli cells.

Species :Human

Expression System:E.coli

Genbank Number :P02778

Storage, Stability and Shipping :The lyophilized protein is stable for at least one year from date of receipt at -70oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :<1.0 EU/μg of recombinant protein as determined by the LAL method.

Molecular Weight :9.0 kDa

Gene Aliases :CXCL10, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Gamma-IP10, Small-inducible cytokine B10, IP10

Reconstitution Protocol :A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Scientific Background :IP-10 shows homology to PF-4 (platelet factor-4) and belongs to the family of chemotactic cytokines known as chemokines. The receptor for IP-10 is CXCR3. IP-10 has been shown to bind to the virus-encoded viroceptor M3. The expression of IP-10 from a variety of cells, including monocytes, endothelial cells, keratinocytes, and fibroblasts, is induced by IFN-gamma and TNF-alpha. Human neutrophils produce IP-10 in response to IFN- gamma in combination with either TNF-alpha or bacterial lipopolysaccharides. IP-10 probably also plays a role in regulation of the growth of immature hematopoietic progenitor cells. It has been shown to suppress in vitro colony formation of highly enriched cells expressing the cell surface marker CD34 in the presence of SCF, GM-CSF, or SCF and EPO, but not in their absence with the exception of SCF.

Sample Cell Assay Data :Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/mL.

Purity :Recombinant Human IP10 (CXCL10) resolved on a 17% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.

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Research Areas :Cancer