IOX1 (8H5QCA)(J48-904D)

IOX1 (8H5QCA)(J48-904D)

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Description :JMJD Demethylase Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :5942-78-8

Molecular Formula :C10H7NO3

Appearance :Yellow powder

Molecular Weight :189.2

Purity :>98% (HPLC)

Solubilization :May be dissolved in DMSO (20 mg/ml)

Aliases :5-Carboxy-8-hydroxyquinoline, 8-Hydroxy-5-quinolinecarboxylic acid

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.

Scientific Background :Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1. A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling1. Cell permeable

References :
1. ON King et al. PLoS One 2010 5:e15535

Molecular Structure :

Product Sheets (By Lot #) :

P3320-22.pdf

Research Areas :Cancer, Cell Cycle, Inflammation