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Imatinib mesylate(A03-901B)

Imatinib mesylate(A03-901B)

  • $39.00


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Description :BCR-ABL inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :220127-57-1

Molecular Formula :C29H31N7O · CH3SO3H

Appearance :White solid

Melting Point :N/A

Molecular Weight :589.7

Purity :98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml)

Aliases :
1. 4-[(4-Methyl-1-piperazinyl) methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl] amino]-phenyl] benzamide methanesulfonate

2. STI-571

Storage and Stability :Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Scientific Background :Tyrosine kinase inhibitor specific for bcr-abl (IC50 = 38 nM) (1), PDGF-R (IC50 = 0.3 uM) (1) and c-kit (IC50 = 0.1 uM) (2). It is a clinically useful anti-cancer drug approved for the treatment of chronic myelogenous leukemia (3), gastrointestinal stromal tumors as well as several other cancers.

References :
1. E Buchdunger et al. Cancer Res. 1996 56:100

2. Heinrich et et al. Blood 2000 96:925

3. M Deininger et al. Pharmacol. Rev. 2003 55:401

Molecular Structure :

Product Sheets (By Lot #) :

T2257-19.pdf

Research Areas :Cancer, Cancer