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Description :Recombinant Human IL17A was expressed in E. coli cells.

Species :Human

Expression System:E.coli

Genbank Number :Q16552

Storage, Stability and Shipping :The lyophilized protein is stable for at least one year from date of receipt at -70oC. Upon reconstitution, this cytokine can be stored in working aliquots at 2o - 8oC for one month, or at -20oC for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :<1.0 EU/μg of recombinant protein as determined by the LAL method

Molecular Weight :16.0 kDa

Gene Aliases :IL-17, CTLA-8, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, Recombinant Human Interleukin-17A (IL17A)

Reconstitution Protocol :A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Scientific Background :The founding member of the IL17 family of cytokines, IL17A plays an important role in antimicrobial and chronic inflammation. All the six IL17 cytokines (IL17A-F) share a cystine knot fold and are secreted as homodimers. Mature human IL17A shares 60% amino acid sequence identity with rat and mouse IL17A. IL17 cytokines bind to two receptors; IL17RA and IL17RC that together form a heterodimer. The receptor heterodimer is preferred by IL17 ligands, and thus, either IL17RA or IL17RC knockouts completely abolish IL17 signalling. Recombinant human IL17A is a non-glycosylated, 32 kDa disulfide-linked homodimer.

Sample Cell Assay Data :The ED(50), as determined by the dose-dependent proliferation of induction of IL6 in primary human foreskin fibroblasts was found to be approximately 2.0 ng/mL, corresponding to a specific activity of > 5.0 x 10^5 units/mg

Purity :Recombinant Human IL17A resolved on a 15% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250

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