IL-8 (72AA)(I868-40N)

IL-8 (72AA)(I868-40N)

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Description :Human active form IL-8 (contains 72 amino acids) with N-terminal His-tag was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Species :Human

Tag :HIS tag

Expression System:E.coli

Sequence :Contains 72 amino acids

Genbank Number :NP_000575.1

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Cell Assay

Endotoxin Level :Less than 0.1 ng/ug (IEU/ug) of IL-8.

Molecular Weight :~11.3 kDa

Gene Aliases :NAF; GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP; NAP-1

Scientific Background :IL-8 or interleukin 8 is a member of the CXC chemokine family that is one of the major mediators of the inflammatory response and several cell types secrete this chemokine. It functions as a chemoattractant, and is also a potent angiogenic factor. IL-8 plays an essential role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection (1). IL8 is produced and released from human adipose tissue and from isolated adipocytes in vitro, which may indicate that IL8 from adipose tissue could be involved in some obesity-related complications (2).

References :
1. Smyth, R. L. et.al: The association between disease severity, cytokines and virus genotype in infants with respiratory syncytial virus (RSV) bronchiolitis. Arch Dis. Child. 82 (Suppl. 1): A4-A5, 2000.

2. Bruun, J. M. et.al : Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro. J. Clin. Endocr. Metab. 86: 1267-1273, 2001.

Product Sheets (By Lot #) :

I111-10.pdf

Research Areas :AKT/PKB Pathway, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, JAK/STAT Pathway, PKA/PKC Pathway