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Description : Recombinant human IFN-gamma was expressed in E. coli cells and purified by proprietary chromatographic techniques.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : tored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Cell Assay
Endotoxin Level : Less than 0.1 ng/ug (IEU/ug) of IFN-gamma.
Molecular Weight : ~17 kDa
Gene Aliases : IFNG; IFG; IFI
Scientific Background : IFN-gamma encodes the ligand-binding chain (alpha) of the gamma interferon receptor which is a heterodimer of IFNGR1 and IFNGR2 and IFNGR1 is associated with susceptibility to Helicobacter pylori infection. IFN-gamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity (1). IFN-gamma is also a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. IFNG is a regulator of hematopoietic stem cells during homeostasis and under conditions of infectious stress (2).
1. Shankaran, V. et.al: IFN-gamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410: 1107-1111, 2001.
2. Baldridge, M. T. et.al: Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 465: 793-797, 2010.
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Research Areas : Apoptosis/Autophagy, Cancer, Inflammation,