IDO2 Protein (I212-30G)
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Description : Full-length recombinant mouse IDO2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Mouse
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full length
Genbank Number : BC026393
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~65 kDa
Gene Aliases : INDOL1
Scientific Background : IDO2 or indoleamine 2,3-dioxygenase 2 encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway which is highly expressed in kidney, epididymis, and liver (1). IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan and it is expressed in a doxycycline-regulated T-REX cell system and monitored formation of N-formyl-kynurenine (Kyn) (2).
1. Ball, H. J.et.al: Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene 396: 203-213, 2007. Note: Erratum: Gene 465: 66 only, 2010.
2. Metz, R.et.al: Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res. 67: 7082-7087, 2007.
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Research Areas : Cell Cycle, Inflammation, Metabolic Disorder,