ICK, Active(I01-10G)

ICK, Active(I01-10G)

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Description :Full-length recombinant human ICK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_014920

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~98 kDa

Gene Aliases :ECO; MRK; KIAA0936; LCK2; MGC46090

Scientific Background :ICK or intestinal cell kinase belongs to a very extensive family of proteins that share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. ICK encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases (1). ICK localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. ICK purified from transfected human embryonic kidney cells undergoes autophosphorylation and phosphorylates a test protein. ICK plays a key role in development of central nervous, skeletal, and endocrine systems (2).

References :
1. Togawa, K. et.al: Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. J. Cell. Physiol. 183: 129-139, 2000.

2. Lahiry, P. et.al: A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems.

Product Sheets (By Lot #) :

W284-1.pdf

N029-4.pdf 

Z1288-1.pdf

V2613-9.pdf

D2338-7.pdf

Research Areas :Cell Cycle, ERK/MAPK Pathway, Ser/Thr Kinases, ERK/MAPK Pathway, Cell Cycle, Ser/Thr Kinases