Anti-p33ING1(I32-363G)
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Description :Goat Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the p33 ING1 protein
Cited Applications :ELISA, WB
Ideal working dilutions for each application should be empirically determined by the investigator.
Cross Reactivity :Human
Host Isotype / Clone# :Goat, IgG
Immunogen :The antibody was produced against synthesized peptide corresponding to amino acids 285-296 of Human p33 ING1 protein (inhibitor of growth family, member 1)
Purification :Immunoaffinity chromatography
Stability :1yr at –20oC from date of shipment
Sample Data :Western blot analysis using anti-p33ING1 (1:1,000 dilution) to detect over expressed Human ING1 present in cell nuclear extracts. This western blot shows reactivity with purified recombinant GST tagged human ING1b (lane 1) and ING1c protein (lane 2).
Scientific Background :p33 ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53-signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. The accession number listed below is for variant (4) that encodes the longest isoform (D). Other synonyms for p33 ING1 include p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a, growth inhibitor ING1, inhibitor of growth 1, tumor suppressor ING1 and growth inhibitory protein ING1.
References :
1. Campos,E.I., et al.: Biological functions of the ING family tumor suppressors. Cell. Mol. Life Sci. 2004: 61 (19-20); 2597-2613.
2. Cheung,K.J., et al.: p33(ING1) enhances UVB-induced apoptosis in melanoma cells. Exp. Cell Res. 2002: 279 (2); 291-298.
3. Vieyra,D. et al.: Human ING1 proteins differentially regulate histone acetylation. J. Biol. Chem. 2002: 277 (33); 29832-29839.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle